Certain factors associated with living with RA also contribute to the increase in osteoporosis risk. These include a sedentary lifestyle. RA is a progressive condition and untreated, can cause damage to joints, which can lead to varying levels of disability. These difficulties in mobility can lead to an involuntary sedentary lifestyle. The lack of physical activity is not your choice, but a consequence of fatigue, pain, and feeling unwell — all symptoms of RA.